GNE-3511

Modify Date: 2024-01-18 14:45:39

GNE-3511 Structure
GNE-3511 structure
Common Name GNE-3511
CAS Number 1496581-76-0 Molecular Weight 440.489
Density 1.4±0.1 g/cm3 Boiling Point 579.0±50.0 °C at 760 mmHg
Molecular Formula C23H26F2N6O Melting Point N/A
MSDS N/A Flash Point 304.0±30.1 °C

 Use of GNE-3511


GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.

 Names

Name 2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile
Synonym More Synonyms

 GNE-3511 Biological Activity

Description GNE-3511 is a dual leucine zipper kinase (DLK) inhibitor with a Ki of 0.5 nM.
Related Catalog
References

[1]. Patel S et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. J Med Chem. 2015 Jan 8;58(1):401-18.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 579.0±50.0 °C at 760 mmHg
Molecular Formula C23H26F2N6O
Molecular Weight 440.489
Flash Point 304.0±30.1 °C
Exact Mass 440.213623
LogP 2.01
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.630
Storage condition 2-8℃

 Synonyms

4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-
2-({6-(3,3-Difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl}amino)isonicotinonitrile
GNE-3511
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