Mequinol

Modify Date: 2024-01-02 09:43:26

Mequinol Structure
Mequinol structure
 Common Name Mequinol
CAS Number 150-76-5 Molecular Weight 124.137
Density 1.1±0.1 g/cm3 Boiling Point 243.0±0.0 °C at 760 mmHg
Molecular Formula C7H8O2 Melting Point 56 °C
MSDS Chinese USA Flash Point 120.8±4.8 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Warning

 Use of Mequinol


Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis spp. Mequinol is used for skin depigmentation[1]

 Names

Name 4-Methoxyphenol
Synonym More Synonyms

 Mequinol Biological Activity

Description Mequinol (4-Methoxyphenol) is one of bioactive components in Mercurialis spp. Mequinol is used for skin depigmentation[1]
Related Catalog
References

[1]. Callender VD, et al. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12(2):87-99.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 243.0±0.0 °C at 760 mmHg
Melting Point 56 °C
Molecular Formula C7H8O2
Molecular Weight 124.137
Flash Point 120.8±4.8 °C
Exact Mass 124.052429
PSA 29.46000
LogP 1.31
Vapour density 4.3 (vs air)
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.535
Stability Stable. Combustible. Incompatible with halogens, oxidizing agents.
Water Solubility 40 g/L (25 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL7700000
CHEMICAL NAME :
Phenol, p-methoxy-
CAS REGISTRY NUMBER :
150-76-5
LAST UPDATED :
199712
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C7-H8-O2
MOLECULAR WEIGHT :
124.15
WISWESSER LINE NOTATION :
QR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7508 ng/kg/12D-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
REFERENCE :
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 54,133,1986 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),31,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 4-METHOXYPHENOL-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3672 No. of Facilities: 9805 (estimated) No. of Industries: 136 No. of Occupations: 89 No. of Employees: 250087 (estimated) No. of Female Employees: 49763 (estimated)

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H317-H319-H361d-H412
Precautionary Statements P201-P273-P280-P308 + P313-P333 + P313-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36;R43
Safety Phrases S24/25-S26-S37/39-S46
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS SL7700000
HS Code 2909500000

 Synthetic Route

 Customs

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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 Synonyms

HQMME
HYDROQUINONE METHYL ETHER
Phenol, p-methoxy-
Hydroquinone monomethyl ether
MEHQ
methylhydroquinone
Anisyl alcohol
p-Hydroxyanisole
Leucobasal
PHENOL,4-METHOXY
Phenol, 4-methoxy-
P-METHOXYPHENOL
mequinol
para-hydroxyanisole
para-methoxy phenol
EINECS 205-769-8
4-Methoxy-phenol
P-GUAIACOL
1-Hydroxy-4-methoxybenzene
4-Hydroxyanisole
4-Methoxyphenol
PARA-METHOXYPHENOL
P-ANISYL ALCOHOL
MFCD00002332
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