7,8-Didehydrocimigenol

Modify Date: 2024-01-15 18:30:13

7,8-Didehydrocimigenol Structure
7,8-Didehydrocimigenol structure
Common Name 7,8-Didehydrocimigenol
CAS Number 150972-72-8 Molecular Weight 486.683
Density 1.2±0.1 g/cm3 Boiling Point 621.8±55.0 °C at 760 mmHg
Molecular Formula C30H46O5 Melting Point N/A
MSDS N/A Flash Point 329.8±31.5 °C

 Use of 7,8-Didehydrocimigenol


7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].

 Names

Name 7,8-Didehydrocimigenol
Synonym More Synonyms

 7,8-Didehydrocimigenol Biological Activity

Description 7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits NF-kB activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis[1].
Related Catalog
References

[1]. Mun L, et al. 7,8-didehydrocimigenol from Cimicifugae rhizoma inhibits TNF-α-induced VCAM-1 but not ICAM-1expression through upregulation of PPAR-γ in human endothelial cells. Food Chem Toxicol. 2011 Jan;49(1):166-72.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 621.8±55.0 °C at 760 mmHg
Molecular Formula C30H46O5
Molecular Weight 486.683
Flash Point 329.8±31.5 °C
Exact Mass 486.334534
LogP 5.31
Vapour Pressure 0.0±4.1 mmHg at 25°C
Index of Refraction 1.601

 Synonyms

(1S,2R,3R,7R,9S,12R,14R,17R,18R,19R,21R,22S)-22-(2-Hydroxy-2-propanyl)-3,8,8,17,19-pentamethyl-23,24-dioxaheptacyclo[19.2.1.01,18.03,17.04,14.07,12.012,14]tetracos-4-ene-2,9-diol
10,12a-Epoxy-2H,5H-cyclopropa[1',8'a]naphth[2',1':4,5]indeno[2,1-b]oxepin-2,13-diol, 1,3,4,6,7,7a,7b,8,9,10,11,13,13a,15,15a-pentadecahydro-11-(1-hydroxy-1-methylethyl)-1,1,7a,8,13a-pentamethyl-, (2S,4aR,5aR,7aR,7bR,8R,10R,11S,12aS,13R,13aR,15aR)-
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