7-Desmethylagomelatine

Modify Date: 2024-01-03 16:24:53

7-Desmethylagomelatine structure	Common Name	7-Desmethylagomelatine
	CAS Number	152302-45-9	Molecular Weight	229.274
	Density	1.2±0.1 g/cm3	Boiling Point	511.3±33.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₅NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	263.0±25.4 °C

Use of 7-Desmethylagomelatine

7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].

Name	N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide
Synonym	More Synonyms

Description	7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64. [2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

Description

7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Millan MJ, et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther. 2003 Sep;306(3):954-64.

[2]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

Density	1.2±0.1 g/cm3
Boiling Point	511.3±33.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₅NO₂
Molecular Weight	229.274
Flash Point	263.0±25.4 °C
Exact Mass	229.110275
PSA	52.82000
LogP	1.62
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.624

HS Code	2924299090

Agomelatine

CAS#:138112-76-2

~79%

7-Desmethylagom...

CAS#:152302-45-9

Literature: Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323

N-[2-(7-hydroxy...

CAS#:296280-78-9

7-Desmethylagom...

CAS#:152302-45-9

Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ; Location in patent: Page/Page column 76 ;

2-(7-Methoxy-1-...

CAS#:139525-77-2

7-Desmethylagom...

CAS#:152302-45-9

Literature: Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239

7-Hydroxy-1-tet...

CAS#:22009-38-7

7-Desmethylagom...

CAS#:152302-45-9

Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ;

Precursor 4
CAS#:138112-76-2 Agomelatine CAS#:296280-78-9 N-[2-(7-hydroxy... CAS#:139525-77-2 2-(7-Methoxy-1-... CAS#:22009-38-7 7-Hydroxy-1-tet...
DownStream 1
CAS#:138112-76-2 Agomelatine

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Acetamide, N-[2-(7-hydroxy-1-naphthalenyl)ethyl]-

7-Demethyl-Agomelatine

N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide

N-[2-(7-Hydroxy-1-naphthyl)ethyl]acetamide

N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide

Agomelatine Impurity 12

7-Desmethylagomelatine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7-Desmethylagomelatine
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 7-Desmethyl-agomelatine
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 7-Desmethyl-agomelatine
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

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7-Desmethylagomelatine

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