BML-278

Modify Date: 2024-01-02 11:57:17

BML-278 Structure
BML-278 structure
Common Name BML-278
CAS Number 15301-69-6 Molecular Weight 391.460
Density 1.2±0.1 g/cm3 Boiling Point 564.1±50.0 °C at 760 mmHg
Molecular Formula C24H25NO4 Melting Point N/A
MSDS N/A Flash Point 294.9±30.1 °C

 Use of BML-278


Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].

 Names

Name flavoxate
Synonym More Synonyms

 BML-278 Biological Activity

Description Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections[1][2].
Related Catalog
References

[1]. Arcaniolo D, et al. Flavoxate: present and future. Eur Rev Med Pharmacol Sci. 2015;19(5):719-31.

[2]. Sugaya K, et al. Intravenous or local injections of flavoxate in the rostral pontine reticular formation inhibit urinary frequency induced by activation of medial frontal lobe neurons in rats. J Urol. 2014 Oct;192(4):1278-85.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 564.1±50.0 °C at 760 mmHg
Molecular Formula C24H25NO4
Molecular Weight 391.460
Flash Point 294.9±30.1 °C
Exact Mass 391.178345
PSA 59.75000
LogP 5.18
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.591

 Synthetic Route

~96%

BML-278 Structure

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Co., Ltd.; Osaka Municipal Government Patent: US4634768 A1, 1987 ;

~92%

BML-278 Structure

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Company, Limited; Osaka Municipal Government Patent: US4533732 A1, 1985 ;

~80%

BML-278 Structure

BML-278

CAS#:15301-69-6

Literature: Yamamoto Chemical Industrial Co., Ltd.; Osaka Municipal Government Patent: US4634768 A1, 1987 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

flavoxate
3-Methylflavone-8-carboxylic Acid b-Piperidinoethyl Ester
Genurin
Flavossato [DCIT]
Flavoxatum [INN-Latin]
3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic Acid 2-(1-Piperidinyl)ethyl Ester
Flavoxato [INN-Spanish]
MFCD00210291
Flavossato
Flavoxate [INN:BAN]
Flavoxatum
REC 7-0040
2-(Piperidin-1-yl)ethyl-3-methyl-4-oxo-2-phenyl-4H-chromen-8-carboxylat
2-(Piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate
2-(1-Piperidinyl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
Urispas
2-piperidin-1-ylethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate
2-Piperidinoethyl 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate
EINECS 239-337-5
Bladderon
Spasuret
2-Piperidinoethyl 3-Methylflavone-8-carboxylate
Flavoxato
4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester