BML-259

Modify Date: 2024-01-05 11:38:01

BML-259 Structure
BML-259 structure
Common Name BML-259
CAS Number 267654-00-2 Molecular Weight 260.35
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C14H16N2OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BML-259


BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].

 Names

Name 2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide
Synonym More Synonyms

 BML-259 Biological Activity

Description BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Related Catalog
In Vitro BML-259 (10 μM) protects large population of cells against non-Aβ component of Alzheimer's disease amyloid (NAC)-evoked cell death[2].
References

[1]. Kaźmierczak A, et al. A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5). Neurochem Int. 2011;58(2):206-214.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C14H16N2OS
Molecular Weight 260.35
Exact Mass 260.098328
PSA 70.23000
LogP 3.88
Index of Refraction 1.618

 Synonyms

2-phenyl-N-[5-(propan-2-yl)-1,3-thiazol-2-yl]acetamide
Benzeneacetamide, N-[5-(1-methylethyl)-2-thiazolyl]-
N-(5-Isopropyl-1,3-thiazol-2-yl)-2-phenylacetamide