APC-6860
Modify Date: 2024-01-09 16:52:01
APC-6860 structure
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Common Name | APC-6860 | ||
|---|---|---|---|---|
| CAS Number | 154628-42-9 | Molecular Weight | 302.13500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H7IN2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of APC-6860APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2]. |
| Name | 4-iodo-1-benzothiophene-2-carboximidamide |
|---|---|
| Synonym | More Synonyms |
| Description | APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2]. |
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| Related Catalog | |
| Target |
uPA:0.21 μM (Ki) trypsin:0.44 μM (Ki) tryptase:1.5 μM (Ki) tPA:16.8 μM (Ki) thrombin:20 μM (Ki) factor Xa:30 μM (Ki) human urokinases:0.1 μM (Ki) murine urokinases:0.082 μM (Ki) |
| In Vitro | APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2]. |
| References |
| Molecular Formula | C9H7IN2S |
|---|---|
| Molecular Weight | 302.13500 |
| Exact Mass | 301.93700 |
| PSA | 78.11000 |
| LogP | 3.59000 |
| 1o5b |
| 1c5n |
| 1c5q |
| 1c5x |