APC 366

Modify Date: 2024-01-23 17:19:56

APC 366 Structure
APC 366 structure
Common Name APC 366
CAS Number 158921-85-8 Molecular Weight 440.496
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H28N6O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of APC 366


APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].

 Names

Name APC 366
Synonym More Synonyms

 APC 366 Biological Activity

Description APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].
Related Catalog
References

[1]. Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63(26):2295-2303.

[2]. Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107(6):1039-1045.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C22H28N6O4
Molecular Weight 440.496
Exact Mass 440.217194
LogP 0.92
Index of Refraction 1.695

 Synonyms

L-Prolinamide, N5-(diaminomethylene)-N2-[(1-hydroxy-2-naphthalenyl)carbonyl]-L-ornithyl-
N5-(Diaminomethylene)-N2-(1-hydroxy-2-naphthoyl)-L-ornithyl-L-prolinamide
N2-[(1-hydroxynaphthalen-2-yl)carbonyl]-L-arginyl-L-prolinamide
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