Compound C108

Modify Date: 2024-01-12 18:06:42

Compound C108 structure	Common Name	Compound C108
	CAS Number	15533-09-2	Molecular Weight	270.283
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₄N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Compound C108

Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2].

Name	Compound C108
Synonym	More Synonyms

Description	Compound C108 is a G3BP2 inhibitor. Compound C108 also targeted stress granule-associated proteins and Gtpase-activating protein (SH3 domain) binding protein 2. Compound C108 potently inhibits esophageal squamous cell carcinoma (ESCC) cell metastasis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	G3BP2[1]
In Vitro	Compound C108 (1 μM; 24 h) 对 BT474 细胞具有抗肿瘤活性[1]。 Compound C108 (4 μM; 24 h) 显著降低过表达 G3BP2 的 KYSE410 细胞和转染 LINC01554的 KYSE30 细胞中 G3BP2 蛋白的表达[2]。 Compound C108 (4 μM; 24 h) 减弱 KYSE410、KYSE30 和 KYSE150 细胞的 ESCC 细胞转移、迁移和侵袭[2]。 Western Blot Analysis[2] Cell Line: G3BP2-overexpressing KYSE410 cells, LINC01554-transfected KYSE30 cells Concentration: 4 μM Incubation Time: 24 h Result: Decreased the protein level of G3BP2 and HDGF.
In Vivo	Compound C108 (1 μM; 24 h) 靶向并减少肿瘤起始细胞 (TICs)，当把 Compound C108 处理过的 BT-474 细胞注射到雌性非肥胖糖尿病/严重联合免疫缺陷 (NOD-SCID) 小鼠的乳腺脂肪垫中，进行有限稀释异种移植试验时，Compound C108 导致肿瘤起始细胞 (TICs) 数目降低[1]。
References	[1]. Gupta N, et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1033-1038. [2]. Zheng Y, et al. G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript. Oncogene. 2022 Jan;41(4):515-526.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₅H₁₄N₂O₃
Molecular Weight	270.283
Exact Mass	270.100433
LogP	3.52
Index of Refraction	1.607

2-Hydroxy-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]benzohydrazide

Benzoic acid, 2-hydroxy-, 2-[(1E)-1-(2-hydroxyphenyl)ethylidene]hydrazide

Compound C108

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Compound C108
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Compound C108
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Delivery: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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