Cysteamine Hydrochloride

Modify Date: 2024-01-02 19:11:54

Cysteamine Hydrochloride Structure
Cysteamine Hydrochloride structure
 Common Name Cysteamine Hydrochloride
CAS Number 156-57-0 Molecular Weight 113.610
Density 0.75 Boiling Point 116.4ºC at 760 mmHg
Molecular Formula C2H8ClNS Melting Point 67-71 °C
MSDS Chinese USA Flash Point 24.2ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Cysteamine Hydrochloride


Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].

 Names

Name Cysteamine hydrochloride
Synonym More Synonyms

 Cysteamine Hydrochloride Biological Activity

Description Cysteamine Hydrochloride is an agent for the treatment of nephropathic cystinosis and an antioxidant.Target: OthersCysteamine has been shown to increase intracellular glutathione levels in cystinotic cells, thus restoring the altered redox state of the cells. Also increased rates of apoptosis in cystinotic cells, which are thought to be the result of increased caspase 3 and protein kinase Cε activity, is counteracted by Cysteamine administration. Cysteamine has antioxidant properties as a result of increasing glutathione production. Cysteamine is an excellent scavenger of OH and HOCl; it also reacts with H2O2. Cysteamine increases the production of several heat shock proteins (HSP), including the murine Hsp40. Cysteamine exerts a dose-dependent effect on the doxorubicin-induced death of cancer cells, measured in both HeLa cells and B16 cells, whereas Cysteamine treatment alone had no influence on cell survival. In addition, in a doxorubicin-resistant breast cancer cell line, the addition of Cysteamine to doxorubicin results in a dramatic increase in cell death [1]. Cysteamine (100 μM) significantly is able to increase the intracellular GSH levels and the percentage of embryos that developed to the blastocyst stage of culture matured oocytes [2].
Related Catalog
References

[1]. Besouw, M., et al., Cysteamine: an old drug with new potential. Drug Discov Today, 2013. 18(15-16): p. 785-92.

[2]. de Matos, D.G., et al., Effect of cysteamine on glutathione level and developmental capacity of bovine oocyte matured in vitro. Mol Reprod Dev, 1995. 42(4): p. 432-6.

 Chemical & Physical Properties

Density 0.75
Boiling Point 116.4ºC at 760 mmHg
Melting Point 67-71 °C
Molecular Formula C2H8ClNS
Molecular Weight 113.610
Flash Point 24.2ºC
Exact Mass 113.006599
PSA 64.82000
LogP 1.37720
Vapour Pressure 16.7mmHg at 25°C
Storage condition 2-8°C
Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility VERY SOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KJ0200000
CHEMICAL NAME :
Ethanethiol, 2-amino-, hydrochloride
CAS REGISTRY NUMBER :
156-57-0
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C2-H7-N-S.Cl-H
MOLECULAR WEIGHT :
113.62
WISWESSER LINE NOTATION :
Z2SH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1352 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
244 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
Micronucleus test

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
5 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 153,57,1985

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37/38
Safety Phrases S36/37/39-S26
RIDADR UN 3335
WGK Germany 3
RTECS KJ0200000
HS Code 2921199090

 Synthetic Route

2-mercapto thiazoline structure

2-mercapto thia...

CAS#:96-53-7

~98%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Cui, Ying; Tan, Shiyu; Luo, Ziping; Dong, Lichun Asian Journal of Chemistry, 2010 , vol. 22, # 4 p. 3221 - 3227
Aziridine structure

Aziridine

CAS#:151-56-4

Nitrogen structure

Nitrogen

CAS#:7727-37-9

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: US5017725 A1, ;
Aziridine structure

Aziridine

CAS#:151-56-4

Nitrogen structure

Nitrogen

CAS#:7727-37-9

2-Butanone structure

2-Butanone

CAS#:78-93-3

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: US5017725 A1, ;
L-alanine structure

L-alanine

CAS#:56-41-7

~61%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Dutta, Anand S.; Giles, Michael, B.; Gormley, James J.; Williams, Joseph C.; Kusner, Edward J. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 111 - 120
2-Chloroethanamine hydrochloride structure

2-Chloroethanam...

CAS#:870-24-6

2-mercapto thiazoline structure

2-mercapto thia...

CAS#:96-53-7

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: US4507500 A1, ;
2-Mercapto-1,3-thiazole structure

2-Mercapto-1,3-...

CAS#:5685-05-2

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Asian Journal of Chemistry, , vol. 24, # 7 p. 3247 - 3248
2-(2-Mercaptoethyl)isoindoline-1,3-dione structure

2-(2-Mercaptoet...

CAS#:4490-75-9

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Chemische Berichte, , vol. 22, p. 1138 Chemische Berichte, , vol. 24, p. 1110
2-Thiazolethiol, 4,5-dihydro- structure

2-Thiazolethiol...

CAS#:134469-06-0

~%

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Agricultural and Biological Chemistry, , vol. 52, # 11 p. 2911 - 2918
hydrochloride salt of (1-chloro-2-acetylamino-2-methyl-1-phenylpropyl) 2-aminoethyl sulfide structure

hydrochloride s...

CAS#:107182-38-7

~%

α-(acetylamino)isobutyrophenone structure

α-(acetylamino)...

CAS#:17582-78-4

Cysteamine Hydrochloride Structure

Cysteamine Hydr...

CAS#:156-57-0

Literature: Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 22, # 2 p. 161 - 166 Khimiya Geterotsiklicheskikh Soedinenii, , vol. 22, # 2 p. 206 - 211

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

2-AMino&CYSTEAMINE HCL
1-Amino-2-mercaptoethane hydrochloride
2-aminoethylmercaptan hydrochloride
2-Mercapto ethyl amine hydrochloride
EINECS 205-858-1
β-Mercapto ethylamine hydrochloride
CYSTEAMINE HCL SOLID
Cysteinamine Hydrochloride
thiol hydrochloride
2-Mercaptoethylamine hydrochloride
Cysteamine Hydrochloride
2-Aminoethanethiol hydrochloride (1:1)
Cysteamine (Hydrochloride)
2-Aminoethanethiol Hydrochloride
Thioethanolamine hydrochloride
2-Mercaptoethanamine Hydrochloride
CYSTEAMINIUM CHLORIDE
2-Mercaptoethylamin
2-amino-ethanethiol hydrochloride
1-Aminoethane-2-thiol hydrochloride
Cysteamine HCl
mea hydrochloride
b-Mercaptoethylamine Hydrochloride
2-Amino-ethanethiol.HCl
Ethanethiol, 2-amino-, hydrochloride (1:1)
β-Mercaptoethylamine hydrochloride
MFCD00012904
Decarboxycysteine hydrochloride
2-Amino-ethanethiol;hydrochloride
2-Mercaptoethylammonium chloride
Aminoethanethiol hydrochloride
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