(R)-SCH 42495

Modify Date: 2024-01-02 18:49:15

(R)-SCH 42495 structure	Common Name	(R)-SCH 42495
	CAS Number	156792-25-5	Molecular Weight	411.58
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₉NO₄S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (R)-SCH 42495

(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[2].

Name	(R)-SCH 42495

Description	(R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1].
In Vivo	Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses[1].
References	[1]. Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37(15):2461-76. [2]. Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68.

Molecular Formula	C₂₀H₂₉NO₄S₂
Molecular Weight	411.58

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