IACS-010759(IACS-10759)

Modify Date: 2024-01-01 20:06:34

IACS-010759(IACS-10759) structure	Common Name	IACS-010759(IACS-10759)
	CAS Number	1570496-34-2	Molecular Weight	562.564
	Density	1.5±0.1 g/cm3	Boiling Point	768.0±70.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₅F₃N₆O₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	418.3±35.7 °C

Use of IACS-010759(IACS-10759)

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

Name	4-(Methylsulfonyl)-1-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]phenyl}piperidine
Synonym	More Synonyms

Description	IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	OXPHOS[1]
In Vitro	IACS-10759 inhibits the conversion of NADH to NAD+ in an immunoprecipitated complex I assay at low nM concentrations[1].
In Vivo	IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg. There is a >50 day extension of median survival in an orthotopic AML cell line xenograft and robust regression in DLBCL and GBM xenograft models[1].
References	[1]. Protopopova M. IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4380. doi:10.1158/1538-7445.AM2015-4380

Density	1.5±0.1 g/cm3
Boiling Point	768.0±70.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₅F₃N₆O₄S
Molecular Weight	562.564
Flash Point	418.3±35.7 °C
Exact Mass	562.161011
LogP	3.91
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.648
Storage condition	-20℃

4-(Methylsulfonyl)-1-{3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]phenyl}piperidine

Piperidine, 4-(methylsulfonyl)-1-[3-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-1,2,4-triazol-1-yl]methyl]phenyl]-

IACS-10759

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: IACS-010759 (IACS-10759)
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: IACS-010759
Price: $850.0/100mg $1500.0/250mg $3000.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: IACS-010759
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-(5-methyl-1-(3-(4-(methylsulfonyl)piperidin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥2723/10 mM * 1 mL in DMSO

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