Upadacitinib tartrate
Modify Date: 2024-01-04 17:09:18
Upadacitinib tartrate structure
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Common Name | Upadacitinib tartrate | ||
|---|---|---|---|---|
| CAS Number | 1607431-21-9 | Molecular Weight | 602.516 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H33F3N6O11 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Upadacitinib tartrateUpadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research[1][2]. |
| Name | Upadacitinib tartrate |
|---|---|
| Synonym | More Synonyms |
| Description | Upadacitinib (ABT-494) tartrate tetrahydrate is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib tartrate tetrahydrate displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib tartrate tetrahydrate can be used for several autoimmune disorders research[1][2]. |
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| Related Catalog | |
| Target |
JAK1:0.043 μM (IC50) JAK2:0.2 μM (IC50) JAK3:2.3 μM (IC50) Tyk2:4.7 μM (IC50) |
| In Vitro | In biochemical assays, Upadacitinib tartrate tetrahydrate is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1]. |
| In Vivo | Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) tartrate tetrahydrate demonstrates efficacy in rat arthritis models[3]. Animal Model: Female Lewis rats (Rat adjuvant-induced arthritis model)[3] Dosage: 0.1, 0.3, 1, 3, 10 mg/kg Administration: Oral gavage; twice a day for 10 days Result: Inhibited disease pathology in rat adjuvant induced arthritis. |
| References |
| Molecular Formula | C21H33F3N6O11 |
|---|---|
| Molecular Weight | 602.516 |
| Exact Mass | 602.215942 |
| Upadacitinib tartrate |
| (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide (2R,3R)-2,3-dihydroxybutanedioate, tetrahydrate |
| (2R,3R)-2,3-Dihydroxysuccinic acid - (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide hydrate (1:1:4) |
| Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide, hydrate (1:1:4) |
| ABT-494 |
| UNII-7KCW9IQM02 |