Tyk2-IN-4(BMS986165)
Modify Date: 2024-01-03 16:53:34
Tyk2-IN-4(BMS986165) structure
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Common Name | Tyk2-IN-4(BMS986165) | ||
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| CAS Number | 1609392-27-9 | Molecular Weight | 425.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H19D3N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tyk2-IN-4(BMS986165)Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2). |
| Name | Tyk2-IN-4 |
|---|
| Description | Tyk2-IN-4 is a selective, potent, allosteric inhibitor of tyrosine kinase 2 (Tyk2). |
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| Related Catalog | |
| Target |
Tyk2 |
| In Vitro | Tyk2-IN-4 blocks receptor-mediated Tyk2 activation by stabilizing the regulatory pseudokinase domain of the protein[1]. |
| In Vivo | Lupus-like disease is strongly inhibited in NZB/W mice treated with Tyk2-IN-4. Tyk2-IN-4 is safe and overall well-tolerated. There are no serious adverse events and the frequency of non-serious adverse events are similar in the active (75%) and placebo (76%) groups. After oral administration, Tyk2-IN-4 is rapidly absorbed and exhibits an apparent elimination half-life of 8-15 hours[1]. |
| References |
| Molecular Formula | C20H19D3N8O3 |
|---|---|
| Molecular Weight | 425.46 |