Alofanib
Modify Date: 2024-01-24 15:57:46
Alofanib structure
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Common Name | Alofanib | ||
|---|---|---|---|---|
| CAS Number | 1612888-66-0 | Molecular Weight | 413.40 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 659.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H15N3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 352.7±34.3 °C | |
Use of AlofanibAlofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer activities[1]. Antiangiogenic Activity[2]. |
| Name | Alofanib |
|---|---|
| Synonym | More Synonyms |
| Description | Alofanib (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Anticancer activities[1]. Antiangiogenic Activity[2]. |
|---|---|
| Related Catalog | |
| Target |
FGFR2 |
| In Vitro | Alofanib inhibits phosphorylation of FRS2α with IC50s of 7 and 9 nM in cancer cells expressing different FGFR2 isoforms[1]. Alofanib (10-1000 nM) inhibits FGF-mediated proliferation in a panel of four cell lines representing several tumour types (triple-negative breast cancer, melanoma, and ovarian cancer with GI50s of 16-370 nM[1]. |
| In Vivo | In a FGFR-driven human tumour xenograft model, oral administration of alofanib (30 mg/kg) is well tolerated and resulted in potent antitumour activity[1]. Treatment with alofanib ablated experimental FGF-induced angiogenesis in vivo[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 659.6±65.0 °C at 760 mmHg |
| Molecular Formula | C19H15N3O6S |
| Molecular Weight | 413.40 |
| Flash Point | 352.7±34.3 °C |
| Exact Mass | 413.068146 |
| LogP | 4.00 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.667 |
| Storage condition | -20℃ |
| 3-{[4-Methyl-2-nitro-5-(3-pyridinyl)phenyl]sulfamoyl}benzoic acid |
| Benzoic acid, 3-[[[4-methyl-2-nitro-5-(3-pyridinyl)phenyl]amino]sulfonyl]- |
| Alofanib (RPT835) |