GLP-1 (9-36) amide TFA

Modify Date: 2024-01-02 08:59:42

GLP-1 (9-36) amide TFA Structure
GLP-1 (9-36) amide TFA structure
Common Name GLP-1 (9-36) amide TFA
CAS Number 161748-29-4 Molecular Weight 3089.41000
Density N/A Boiling Point N/A
Molecular Formula C140H214N36O43 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GLP-1 (9-36) amide TFA


GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor[1][2].

 Names

Name GLP-1 (9-36) amide
Synonym More Synonyms

 GLP-1 (9-36) amide TFA Biological Activity

Description GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor[1][2].
Related Catalog
In Vitro GLP-1(9-36)amide potently inhibits hepatic glucose production (HGP) and is a weak insulinotropic agent[2].
References

[1]. Knudsen LB, et al. Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor. Eur J Pharmacol. 1996;318(2-3):429-435.

[2]. Elahi D, et al. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring). 2008;16(7):1501-1509.

 Chemical & Physical Properties

Molecular Formula C140H214N36O43
Molecular Weight 3089.41000
Exact Mass 3087.57000
PSA 1298.21000
LogP 2.29160

 Synonyms

h-glu-gly-thr-phe-thr-ser-asp-val-ser-ser-tyr-leu-glu-gly-gln-ala-ala-lys-glu-phe-ile-ala-trp-leu-val-lys-gly-arg-nh2
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