BM-1244

Modify Date: 2024-01-14 18:36:30

BM-1244 Structure
BM-1244 structure
Common Name BM-1244
CAS Number 1619923-32-8 Molecular Weight 1159.79
Density N/A Boiling Point N/A
Molecular Formula C54H59ClF4N6O8S4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BM-1244


BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].

 Names

Name BM-1244

 BM-1244 Biological Activity

Description BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1)[1].
Related Catalog
References

[1]. Jill Hopkins, et al. Treatment of ophthalmic conditions such as macular degeneration, glaucoma, and diabetic retinopathy using pharmaceutical agents that eliminate senescent cells. WO2019033119A1.

[2]. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun. 2005;333(2):336-343.

 Chemical & Physical Properties

Molecular Formula C54H59ClF4N6O8S4
Molecular Weight 1159.79