RWJ 50271

Modify Date: 2024-01-16 13:43:03

RWJ 50271 Structure
RWJ 50271 structure
Common Name RWJ 50271
CAS Number 162112-37-0 Molecular Weight 410.41
Density N/A Boiling Point N/A
Molecular Formula C18H17F3N4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RWJ 50271


RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].

 Names

Name N-(3-Hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3 -thiazol-2-yl}-1H-pyrazole-4-carboxamide

 RWJ 50271 Biological Activity

Description RWJ 50271 is an selective inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells)[1].
Related Catalog
Target

IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells)[1]

References

[1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9.

 Chemical & Physical Properties

Molecular Formula C18H17F3N4O2S
Molecular Weight 410.41
Exact Mass 410.10200
PSA 111.77000
LogP 4.01000