NTRC 824
Modify Date: 2024-01-08 12:31:05
NTRC 824 structure
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Common Name | NTRC 824 | ||
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| CAS Number | 1623002-61-8 | Molecular Weight | 553.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H26F3N3O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NTRC 824NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1]. |
| Name | NTRC-824 |
|---|
| Description | NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1]. |
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| Related Catalog | |
| Target |
IC50: 38 nM (Nurotensin receptor type 2)[1] Ki: 202 nM (Nurotensin receptor type 2)[1] |
| In Vitro | Testing of NTRC-824 (Compound 5) at the NTS1 receptor shows no binding activity in the NTS1 assay up to 30 μM, making NTRC-824 (Compound 5) selective for NTS2 in both the binding and functional assays. NTRC-824 (Compound 5) is the first nonpeptide compound that behaves like, and is more active than, the endogenous ligand[1]. |
| References |
| Molecular Formula | C25H26F3N3O6S |
|---|---|
| Molecular Weight | 553.55 |