Vitamin D3-d7

Modify Date: 2024-01-16 15:14:43

Vitamin D3-d7 Structure
Vitamin D3-d7 structure
Common Name Vitamin D3-d7
CAS Number 1627523-19-6 Molecular Weight 391.681
Density 1.0±0.1 g/cm3 Boiling Point 496.4±24.0 °C at 760 mmHg
Molecular Formula C27H37D7O Melting Point N/A
MSDS N/A Flash Point 214.2±15.1 °C

 Use of Vitamin D3-d7


Vitamin D3-D7 (Cholecalciferol-D7) is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].

 Names

Name Vitamin D3-d7
Synonym More Synonyms

 Vitamin D3-d7 Biological Activity

Description Vitamin D3-D7 (Cholecalciferol-D7) is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Nazik Al-Hashimi, et al. Cholecalciferol

[3]. Laura Bergadà, et al. Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma. Lab Invest. 2014 Jun;94(6):608-22

[4]. Hiroki Yoshioka, et al. Vitamin D3-induced hypercalcemia increases carbon tetrachloride-induced hepatotoxicity through elevated oxidative stress in mice. PLoS One. 2017 Apr 27;12(4):e0176524.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 496.4±24.0 °C at 760 mmHg
Molecular Formula C27H37D7O
Molecular Weight 391.681
Flash Point 214.2±15.1 °C
Exact Mass 391.383148
LogP 9.72
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.523

 Synonyms

(3S,5Z,7E)-(25,26,26,26,27,27,27-2H7)-9,10-Secocholesta-5,7,10-trien-3-ol
Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R)-1-methyl-5-(methyl-d3)hexyl-5,6,6,6-d4]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-
VITAMIN D3-D7