WIN 64338 hydrochloride
Modify Date: 2024-01-13 11:44:00
WIN 64338 hydrochloride structure
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Common Name | WIN 64338 hydrochloride | ||
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| CAS Number | 163727-74-0 | Molecular Weight | 783.935 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C45H69Cl2N4OP | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WIN 64338 hydrochlorideWIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2]. |
| Name | (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride |
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| Synonym | More Synonyms |
| Description | WIN 64338 hydrochloride is a potent, selective, nonpeptide competitive antagonist of bradykinin B2 receptor. WIN 64338 hydrochloride inhibits [3H]-Bradykinin binding to the bradykinin B2 receptor on human IMR-90 cells with a Ki of 64 nM. WIN 64338 hydrochloride also can inhibits [3H]Quinuclidinyl benzilate binding to the rat brain muscarinic receptor (Ki=350 nM)[1][2]. |
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| Related Catalog | |
| Target |
Ki: 64 nM (bradykinin B2 receptor)[1], 350 nM (muscarinic receptor)[2] |
| In Vitro | WIN 64338 hydrochloride competitively inhibits Bradykinin-stimulated 45Ca2+ efflux from IMR-90 cells (pA2=7.1)[1]. WIN 64338 hydrochloride inhibits Bradykinin-mediated guinea pig ileum contractility (pA2=8.2)[1]. WIN 64338 hydrochloride inhibits Bradykinin-induced contraction of guinea-pig trachea, with a KB of 64.3 nM[2]. |
| In Vivo | WIN 64338 (5 mg/kg; i.p.) hydrochloride decreases the physiological anxiety measure, stress-induced hyperthermia (SIH) of mice[3]. |
| References |
| Molecular Formula | C45H69Cl2N4OP |
|---|---|
| Molecular Weight | 783.935 |
| Exact Mass | 782.458618 |
| (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride |
| Phosphonium, tributyl[[4-[[(2S)-2-[[(E)-(cyclohexylamino)(cyclohexylimino)methyl]amino]-3-(2-naphthalenyl)-1-oxopropyl]amino]phenyl]methyl]-, chloride, hydrochloride (1:1:1) |
| N2-(N,N'-Dicyclohexylcarbamimidoyl)-3-(2-naphthyl)-N-{4-[(tributylphosphonio)methyl]phenyl}-L-alaninamide chloride hydrochloride (1:1:1) |
| phosphonium, tributyl[[4-[[(2S)-2-[[(E)-(cyclohexylamino)(cyclohexyliminio)methyl]amino]-3-(2-naphthalenyl)-1-oxopropyl]amino]phenyl]methyl]-, chloride (1:2) |