LolCDE-IN-1

Modify Date: 2024-01-17 20:02:49

LolCDE-IN-1 Structure
LolCDE-IN-1 structure
Common Name LolCDE-IN-1
CAS Number 1639933-78-0 Molecular Weight 345.37
Density N/A Boiling Point N/A
Molecular Formula C21H16FN3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LolCDE-IN-1


LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].

 Names

Name LolCDE-IN-1

 LolCDE-IN-1 Biological Activity

Description LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].
Related Catalog
Target

Bacterial

In Vitro LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane[1]. LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml[1]. LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane[1].
References

[1]. Nayar AS, et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

 Chemical & Physical Properties

Molecular Formula C21H16FN3O
Molecular Weight 345.37
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