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1639933-78-0

1639933-78-0 structure
1639933-78-0 structure
  • Name: LolCDE-IN-1
  • Chemical Name: LolCDE-IN-1
  • CAS Number: 1639933-78-0
  • Molecular Formula: C21H16FN3O
  • Molecular Weight: 345.37
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2020-04-06 16:38:30
  • Modify Date: 2024-01-17 20:02:49
  • LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].

Name LolCDE-IN-1
Description LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex, with antibacterial activity[1].
Related Catalog
Target

Bacterial

In Vitro LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane[1]. LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml[1]. LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane[1].
References

[1]. Nayar AS, et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

Molecular Formula C21H16FN3O
Molecular Weight 345.37