BIBU 1361 dihydrochloride
Modify Date: 2024-09-14 18:26:26
BIBU 1361 dihydrochloride structure
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Common Name | BIBU 1361 dihydrochloride | ||
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| CAS Number | 1643609-75-9 | Molecular Weight | 516.870 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H29Cl3FN7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BIBU 1361 dihydrochlorideBIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM); inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM); demonstrates effectivity in tumour xenografts mice. |
| Name | N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]-1-piperidinyl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride |
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| Synonym | More Synonyms |
| Description | BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM); inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM); demonstrates effectivity in tumour xenografts mice. |
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| References | References 1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. 2. Ghildiyal R, et al. Mol Carcinog. 2013 Dec;52(12):970-82. View Related Products by Target EGFR |
| Molecular Formula | C22H29Cl3FN7 |
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| Molecular Weight | 516.870 |
| Exact Mass | 515.153381 |
| N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]-1-piperidinyl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride |
| Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-, hydrochloride (1:2) |
| N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]piperidin-1-yl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride |