1643609-75-9

1643609-75-9 structure

Name: BIBU 1361 dihydrochloride
Chemical Name: N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]-1-piperidinyl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride
CAS Number: 1643609-75-9
Molecular Formula: C₂₂H₂₉Cl₃FN₇
Molecular Weight: 516.870
Create Date: 2020-01-11 18:37:50
Modify Date: 2023-04-05 14:18:49
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM); inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM); demonstrates effectivity in tumour xenografts mice.

Name	N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]-1-piperidinyl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride
Synonyms	N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]-1-piperidinyl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride Pyrimido[5,4-d]pyrimidin-4-amine, N-(3-chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-, hydrochloride (1:2) N-(3-Chloro-4-fluorophenyl)-6-{4-[(diethylamino)methyl]piperidin-1-yl}pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride

Description	BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM); inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM); demonstrates effectivity in tumour xenografts mice.
References	References 1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. 2. Ghildiyal R, et al. Mol Carcinog. 2013 Dec;52(12):970-82. View Related Products by Target EGFR