sb 220025
Modify Date: 2024-01-12 17:48:58
sb 220025 structure
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Common Name | sb 220025 | ||
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| CAS Number | 165806-53-1 | Molecular Weight | 338.38 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19FN6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of sb 220025SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2]. |
| Name | sb 220025 |
|---|
| Description | SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2]. |
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| Related Catalog | |
| Target |
p38:60 nM (IC50) p56-Lck:3.5 μM (IC50) PKC:2.89 μM (IC50) |
| In Vitro | SB 220025 (20 μM; 6 h) 显着降低 HUVEC 细胞中响应球型脂联素 (gAd) 的 IL-8 基因表达[1]。 RT-PCR[1] Cell Line: HUVEC cells Concentration: 20 μM Incubation Time: 6 h Result: Inhibited MCP-1 gene expression. |
| In Vivo | SB 220025 (3-50 mg/kg; p.o.; single) 可抑制体内炎症细胞因子的产生[2]。 SB 220025 (5, 30, 50 mg/kg; i.p.; bid) 抑制小鼠气囊肉芽肿模型的血管生成[2]。 SB 220025 (30 mg/kg; p.o.; twice a day for 3, 5, 7 or 14 days) 防止小鼠气囊血管生成模型第 3 天后发生的血管生成增加[2]。 SB 220025 (50 mg/kg; p.o.; b.i.d.; 10 days) 在慢性炎症疾病模型中有效地阻止关节炎的进展[2]。 Animal Model: Acute model of LPS-induced TNF-a expression[2]. Dosage: 3-50 mg/kg Administration: Oral administration; single; 30 min before challenge with LPS. Result: Dosedependently inhibited TNF-a production with an ED50 value of 7.5 mg/kg, and showed more than 80% inhibition when at 50 mg/kg. Animal Model: Murine air pouch granuloma model[2]. Dosage: 5, 30, 50 mg/kg Administration: Intraperitoneal injection; bisindie (bid, twice a day). Result: Caused a dose-dependent reduction in angiogenesis. Animal Model: Murine air pouch granuloma model[2]. Dosage: 30 mg/kg Administration: Oral administration; twice a day from day 0 until removal of granuloma tissue at days 3, 5, 7 or 14. Result: Did not affect the initial burst of angiogenesis but did prevent the increase in angiogenesis that occurs after day 3. |
| References |
| Molecular Formula | C18H19FN6 |
|---|---|
| Molecular Weight | 338.38 |
| Exact Mass | 338.16600 |
| PSA | 81.65000 |
| LogP | 3.56290 |
| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SB220025
- Price: Negotiable
- Purity: 95.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: SB 220025
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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