Hydroxy-PEG3-acrylate

Modify Date: 2024-04-02 17:18:46

Hydroxy-PEG3-acrylate Structure
Hydroxy-PEG3-acrylate structure
Common Name Hydroxy-PEG3-acrylate
CAS Number 16695-45-7 Molecular Weight 204.22000
Density 1.098g/cm3 Boiling Point 302.4ºC at 760mmHg
Molecular Formula C9H16O5 Melting Point N/A
MSDS N/A Flash Point 113ºC

 Use of Hydroxy-PEG3-acrylate


Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(2-hydroxyethoxy)ethoxy]ethyl prop-2-enoate
Synonym More Synonyms

 Hydroxy-PEG3-acrylate Biological Activity

Description Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.098g/cm3
Boiling Point 302.4ºC at 760mmHg
Molecular Formula C9H16O5
Molecular Weight 204.22000
Flash Point 113ºC
Exact Mass 204.10000
PSA 64.99000
Vapour Pressure 9.63E-05mmHg at 25°C
Index of Refraction 1.453

 Safety Information

HS Code 2916129000

 Synthetic Route

~48%

Hydroxy-PEG3-acrylate Structure

Hydroxy-PEG3-ac...

CAS#:16695-45-7

Literature: Philippon, Annie; Tao, Jingchao; Tetard, David; Degueil-Castaing, Marie; Maillard, Bernard Synthetic Communications, 1997 , vol. 27, # 15 p. 2651 - 2682

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Hydroxy-PEG3-acrylate Structure

Hydroxy-PEG3-ac...

CAS#:16695-45-7

Detail
Literature: BASF AKTIENGESELLSCHAFT Patent: WO2004/14837 A1, 2004 ; Location in patent: Page/Page column 19-20 ;

 Customs

HS Code 2916129000
Summary 2916129000 other esters of acrylic acid VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Synonyms

ethylenediglycol acrylate
EINECS 240-741-9
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl acrylate
triethylene glycol monoacrylate
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