Hydroxy-PEG3-(CH2)2-Boc

Modify Date: 2024-01-03 13:47:18

Hydroxy-PEG3-(CH2)2-Boc structure	Common Name	Hydroxy-PEG3-(CH2)2-Boc
	CAS Number	186020-66-6	Molecular Weight	278.34200
	Density	1.057g/cm3	Boiling Point	365.8ºC at 760 mmHg
	Molecular Formula	C₁₃H₂₆O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	125.2ºC

Use of Hydroxy-PEG3-(CH2)2-Boc

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].

Name	tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate
Synonym	More Synonyms

Description	Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Density	1.057g/cm3
Boiling Point	365.8ºC at 760 mmHg
Molecular Formula	C₁₃H₂₆O₆
Molecular Weight	278.34200
Flash Point	125.2ºC
Exact Mass	278.17300
PSA	74.22000
LogP	0.76030
Vapour Pressure	7.78E-07mmHg at 25°C
Index of Refraction	1.45

Hydroxy-PEG3-(CH2)2-Boc MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2918990090

tert-Butyl acrylate

CAS#:1663-39-4

Triethylene glycol

CAS#:112-27-6

~94%

Hydroxy-PEG3-(C...

CAS#:186020-66-6

Literature: Wilbur, D. Scott; Pathare, Pradip M.; Hamlin, Donald K.; Wan, Feng Patent: US2006/228325 A1, 2006 ; Location in patent: Page/Page column 63 ;

Precursor 2
CAS#:1663-39-4 tert-Butyl acrylate CAS#:112-27-6 Triethylene glycol
DownStream 1
CAS#:166668-33-3 T-BUTYL TRANS-1...

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%