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518044-31-0

518044-31-0 structure
518044-31-0 structure
  • Name: Hydroxy-PEG3-CH2-Boc
  • Chemical Name: 2-Methyl-2-propanyl {2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}acetate
  • CAS Number: 518044-31-0
  • Molecular Formula: C12H24O6
  • Molecular Weight: 264.315
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-24 01:46:24
  • Modify Date: 2024-01-09 16:54:09
  • Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl {2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}acetate
Synonyms 2-Methyl-2-propanyl {2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}acetate
Acetic acid, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
MFCD27977510
Description Hydroxy-PEG3-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 351.2±27.0 °C at 760 mmHg
Molecular Formula C12H24O6
Molecular Weight 264.315
Flash Point 121.9±17.2 °C
Exact Mass 264.157288
LogP 0.11
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.449