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297162-47-1

297162-47-1 structure
297162-47-1 structure
  • Name: Hydroxy-PEG6-CH2-Boc
  • Chemical Name: 2-Methyl-2-propanyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosan-1-oate
  • CAS Number: 297162-47-1
  • Molecular Formula: C18H36O9
  • Molecular Weight: 396.473
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-24 19:44:21
  • Modify Date: 2024-01-10 08:31:18
  • Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosan-1-oate
Synonyms 2-Methyl-2-propanyl 20-hydroxy-3,6,9,12,15,18-hexaoxaicosan-1-oate
3,6,9,12,15,18-Hexaoxaeicosan-1-oic acid, 20-hydroxy-, 1,1-dimethylethyl ester
Description Hydroxy-PEG6-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 469.5±40.0 °C at 760 mmHg
Molecular Formula C18H36O9
Molecular Weight 396.473
Flash Point 151.3±20.8 °C
Exact Mass 396.235931
LogP -0.96
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.456