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287174-32-7

287174-32-7 structure
287174-32-7 structure
  • Name: Hydroxy-PEG1-CH2-Boc
  • Chemical Name: 2-Methyl-2-propanyl (2-hydroxyethoxy)acetate
  • CAS Number: 287174-32-7
  • Molecular Formula: C8H16O4
  • Molecular Weight: 176.210
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-03 08:05:30
  • Modify Date: 2024-01-16 20:40:56
  • Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-Methyl-2-propanyl (2-hydroxyethoxy)acetate
Synonyms 2-Methyl-2-propanyl (2-hydroxyethoxy)acetate
Acetic acid, 2-(2-hydroxyethoxy)-, 1,1-dimethylethyl ester
MFCD27635155
Description Hydroxy-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.0±0.1 g/cm3
Boiling Point 257.0±15.0 °C at 760 mmHg
Molecular Formula C8H16O4
Molecular Weight 176.210
Flash Point 95.2±13.9 °C
Exact Mass 176.104858
LogP 0.83
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.438
Hazard Codes Xi