Hydroxy-PEG1-(CH2)2-Boc

Modify Date: 2024-01-05 16:02:17

Hydroxy-PEG1-(CH2)2-Boc Structure
Hydroxy-PEG1-(CH2)2-Boc structure
Common Name Hydroxy-PEG1-(CH2)2-Boc
CAS Number 671802-00-9 Molecular Weight 190.23700
Density 1.031±0.06 g/cm3(Predicted) Boiling Point 274.0±15.0℃at 760 mmHg
Molecular Formula C9H18O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hydroxy-PEG1-(CH2)2-Boc


Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl 3-(2-hydroxyethoxy)propanoate
Synonym More Synonyms

 Hydroxy-PEG1-(CH2)2-Boc Biological Activity

Description Hydroxy-PEG1-(CH2)2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.031±0.06 g/cm3(Predicted)
Boiling Point 274.0±15.0℃at 760 mmHg
Molecular Formula C9H18O4
Molecular Weight 190.23700
Exact Mass 190.12100
PSA 55.76000
LogP 0.72710

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
Product Name: tert-Butyl 3-(2-hydroxyethoxy)propanoate
Synonyms:

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:tert-Butyl 3-(2-hydroxyethoxy)propanoate
CAS number:671802-00-9

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C9H18O4
Molecular weight:190.2

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi

 Synthetic Route

~24%

Hydroxy-PEG1-(CH2)2-Boc Structure

Hydroxy-PEG1-(C...

CAS#:671802-00-9

Literature: AMBRX, INC.; BARNETT, Richard S.; TIAN, Feng; PUTNAM, Anna-maria A. Hays; GYMNOPOULOS, Marco; KNUDSEN, Nick; BECK, Andrew; SUN, Ying Patent: WO2013/185117 A1, 2013 ; Location in patent: Paragraph 00476 ;

 Synonyms

MFCD22056310
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Hydroxy-PEG1-(CH2)2-Boc suppliers


Price: ¥550/100 mg

Reference only. check more Hydroxy-PEG1-(CH2)2-Boc price