Bradykinin Fragment 2-9

Modify Date: 2024-01-09 20:24:18

Bradykinin Fragment 2-9 structure	Common Name	Bradykinin Fragment 2-9
	CAS Number	16875-11-9	Molecular Weight	904.02300
	Density	1.47g/cm3	Boiling Point	N/A
	Molecular Formula	C₄₄H₆₁N₁₁O₁₀	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Bradykinin Fragment 2-9

Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

Name	5-(diaminomethylideneamino)-2-[[2-[[1-[3-hydroxy-2-[[3-phenyl-2-[[2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]pentanoic acid
Synonym	More Synonyms

Description	Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor Research Areas >> Cardiovascular Disease Peptides
In Vitro	The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].
References	[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Density	1.47g/cm3
Molecular Formula	C₄₄H₆₁N₁₁O₁₀
Molecular Weight	904.02300
Exact Mass	903.46000
PSA	317.58000
LogP	0.95140
Index of Refraction	1.684
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.

Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012)

In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp ...

Accurate mass measurements using MALDI-TOF with delayed extraction.

J. Protein Chem. 16(5) , 363-9, (1997)

Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass range are unsurpassed, but mass measureme...

Shattering of Peptide ions on self-assembled monolayer surfaces.

J. Am. Chem. Soc. 125(6) , 1625-32, (2003)

Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fo...

L-Phe-L-Trp-OH

H-PPGFSPFR-OH

bradykinin fragment 2-9

n-l-phenylalanyl-l-tryptopha

L-PHENYLALANYL-L-TRYPTOPHAN

Phe-Trp-OH

des-[Arg1]-bradykinin

phenylalanyltryptophane

des-Arg9-bradykinin

phenylalanyltryptophan

Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Bradykinin (2-9)