RS 67333 hydrochloride
Modify Date: 2024-01-11 16:05:22
RS 67333 hydrochloride structure
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Common Name | RS 67333 hydrochloride | ||
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| CAS Number | 168986-60-5 | Molecular Weight | 389.36000 | |
| Density | N/A | Boiling Point | 502.3ºC at 760mmHg | |
| Molecular Formula | C19H30Cl2N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 257.6ºC | |
Use of RS 67333 hydrochlorideRS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research[1]. |
| Name | 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one,hydrochloride |
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| Description | RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research[1]. |
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| Related Catalog | |
| Target |
5-HT4 Receptor:8.7 (pKi) |
| In Vitro | RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT[1]. |
| References |
| Boiling Point | 502.3ºC at 760mmHg |
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| Molecular Formula | C19H30Cl2N2O2 |
| Molecular Weight | 389.36000 |
| Flash Point | 257.6ºC |
| Exact Mass | 388.16800 |
| PSA | 55.56000 |
| LogP | 5.72690 |
| Vapour Pressure | 3.22E-10mmHg at 25°C |
| Storage condition | -20°C |
| HS Code | 2933399090 |
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| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |