Treprostinil palmitil

Modify Date: 2024-01-10 12:47:13

Treprostinil palmitil Structure
Treprostinil palmitil structure
Common Name Treprostinil palmitil
CAS Number 1706528-83-7 Molecular Weight 614.94
Density 1.0±0.1 g/cm3 Boiling Point 705.7±60.0 °C at 760 mmHg
Molecular Formula C39H66O5 Melting Point N/A
MSDS N/A Flash Point 204.5±26.4 °C

 Use of Treprostinil palmitil


Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors[1][2].

 Names

Name TREPROSTINIL HEXADECYL ESTER
Synonym More Synonyms

 Treprostinil palmitil Biological Activity

Description Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors[1][2].
Related Catalog
References

[1]. Chapman RW, Corboz MR, Malinin VS, Plaunt AJ, Konicek DM, Li Z, Perkins WR. An overview of the biology of a long-acting inhaled treprostinil prodrug. Pulm Pharmacol Ther. 2020 Dec;65:102002.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 705.7±60.0 °C at 760 mmHg
Molecular Formula C39H66O5
Molecular Weight 614.94
Flash Point 204.5±26.4 °C
Exact Mass 614.491028
LogP 12.44
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.510

 Synonyms

Acetic acid, 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]-, hexadecyl ester
TREPROSTINIL HEXADECYL ESTER
Hexadecyl ({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetate
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