AN2718

Modify Date: 2024-01-10 12:37:41

Use of AN2718

AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.

Name	5-chloro-1-hydroxy-3H-2,1-benzoxaborole
Synonym	More Synonyms

Description	AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Infection
Target	Fungal[1].
In Vitro	AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes[1].
References	[1]. Seiradake, et al. Antifungal activity and mechanism of action of a benzoxaborole, AN2718, which is in development for the treatment of tinea pedis. 48th Annual ICAAC/46th Annual IDSA (2008).

5-chloro-1,3-dihydro-2,1-benzoxaborol-1-ol

2,1-Benzoxaborole,5-chloro-1,3-dihydro-1-hydroxy

UNII-810U6C2DGG

5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

AN2718

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