9-Decyn-1-ol

Modify Date: 2024-01-14 16:37:55

9-Decyn-1-ol Structure
9-Decyn-1-ol structure
 Common Name 9-Decyn-1-ol
CAS Number 17643-36-6 Molecular Weight 154.249
Density 0.9±0.1 g/cm3 Boiling Point 232.1±23.0 °C at 760 mmHg
Molecular Formula C10H18O Melting Point N/A
MSDS N/A Flash Point 171.8±14.9 °C

 Use of 9-Decyn-1-ol


9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].

 Names

Name dec-9-yn-1-ol
Synonym More Synonyms

 9-Decyn-1-ol Biological Activity

Description 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].
Related Catalog
Target

Alkyl/ether

In Vitro 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1].
References

[1]. You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27(1):66-73.e7.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 232.1±23.0 °C at 760 mmHg
Molecular Formula C10H18O
Molecular Weight 154.249
Flash Point 171.8±14.9 °C
Exact Mass 154.135757
PSA 20.23000
LogP 2.71
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.458

 Safety Information

HS Code 2905290000

 Synthetic Route

 Customs

HS Code 2905290000
Summary 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

10-Hydroxy-1-decyne
dec-9-yn-1-ol
9-Decyn-1-ol
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Chemsrc provides 9-Decyn-1-ol(CAS#:17643-36-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 9-Decyn-1-ol are included as well.>> amp version: 9-Decyn-1-ol

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