17643-36-6
17643-36-6 structure
- Name: 9-Decyn-1-ol
- Chemical Name: dec-9-yn-1-ol
- CAS Number: 17643-36-6
- Molecular Formula: C10H18O
- Molecular Weight: 154.249
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-24 12:38:10
- Modify Date: 2024-01-14 16:37:55
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9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1].
| Name | dec-9-yn-1-ol |
|---|---|
| Synonyms |
10-Hydroxy-1-decyne
dec-9-yn-1-ol 9-Decyn-1-ol |
| Description | 9-Decyn-1-ol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker[1]. |
| References |
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 232.1±23.0 °C at 760 mmHg |
| Molecular Formula | C10H18O |
| Molecular Weight | 154.249 |
| Flash Point | 171.8±14.9 °C |
| Exact Mass | 154.135757 |
| PSA | 20.23000 |
| LogP | 2.71 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.458 |
| HS Code | 2905290000 |
|---|
| HS Code | 2905290000 |
|---|---|
| Summary | 2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |