Hematoporphyrin (dihydrochloride)

Modify Date: 2024-01-05 17:03:34

Hematoporphyrin (dihydrochloride) Structure
Hematoporphyrin (dihydrochloride) structure
 Common Name Hematoporphyrin (dihydrochloride)
CAS Number 17696-69-4 Molecular Weight 671.611
Density N/A Boiling Point 1192.7ºC at 760 mmHg
Molecular Formula C34H40Cl2N4O6 Melting Point N/A
MSDS N/A Flash Point 675.1ºC

 Use of Hematoporphyrin (dihydrochloride)


Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.Target: OthersHematoporphyrin is used for affinity chromatography of heme-binding proteins. Hematoporphyrin is used in the characterization and synthesis of hematoporphyrin- and hematin-agarose [1].

 Names

Name Hematoporphyrin IX dihydrochloride,8,13-Bis(1-hydroxyethyl)-3,7,12,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid dihydrochloride
Synonym More Synonyms

 Hematoporphyrin (dihydrochloride) Biological Activity

Description Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.Target: OthersHematoporphyrin is used for affinity chromatography of heme-binding proteins. Hematoporphyrin is used in the characterization and synthesis of hematoporphyrin- and hematin-agarose [1].
Related Catalog
References

[1]. Olsen, K.W., Affinity chromatography of heme-binding proteins: synthesis and characterization of hematin- and hematoporphyrin-agarose. Methods Enzymol, 1986. 123: p. 324-31.

 Chemical & Physical Properties

Boiling Point 1192.7ºC at 760 mmHg
Molecular Formula C34H40Cl2N4O6
Molecular Weight 671.611
Flash Point 675.1ºC
Exact Mass 670.232483
PSA 171.36000
LogP 4.24970
Vapour Pressure 0mmHg at 25°C
Storage condition 2-8°C
Water Solubility Insoluble in water. Soluble in pyridine (5%).

 MSDS

Section 1: Product Identification
Chemical Name:Hematoporphyrin IX dihydrochloride
CAS Registry Number:17696-69-4
Formula:C34H38N4O6.2HCl
EINECS Number:241-699-4
Chemical Family:porphine (porphyrin) ligand
Synonym:none
Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound17696-69-4100%no datano data
Section 3: Hazards Identification
Emergency Overview:No particular hazard associated with this material.
Primary Routes of Exposure:Ingestion, inhalation
Eye Contact:May cause slight to mild irritation of the eyes.
Skin Contact:May cause slight to mild irritation of the skin.
Inhalation:May be irritating to the nose, mucous membranes and respiratory tract.
Ingestion:No specific information is available on the physiological effects of ingestion.
Acute Health Affects:May be irritating to skin, eyes and respiratory tract.
Chronic Health Affects:No information available on long-term chronic effects.
NTP:No
IARC:No
OSHA:No
SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.
SECTION 5: Fire Fighting Measures
Flash Point:no data
Autoignition Temperature:none
Explosion Limits:none
Extinguishing Medium:carbon dioxide, dry powder or foam
If this material is involved in a fire, fire fighters should be equipped with a NIOSH approved, positive pressure
Special Fire Fighting Procedures:
self contained breathing apparatus and full protective clothing.
Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.
SECTION 6: Accidental Release Measures
Spill and Leak Procedures:Small spills can be mixed with vermiculite or sodium carbonate and swept up.
SECTION 7: Handling and Storage
Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight.
SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear protective clothing and gloves.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.
SECTION 9: Physical and Chemical Properties
Color and Form:purple xtl.
Molecular Weight:671.62
Melting Point:no data
Boiling Point:no data
Vapor Pressure:no data
Specific Gravity:no data
Odor:none
Solubility in Water:insoluble
SECTION 10: Stability and Reactivity
Stability:air and moisture stable solid
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:none
Incompatibility:oxidizing agents
Decomposition Products:carbon dioxide, carbon monoxide, nitrogen oxides, and organic fumes
SECTION 11: Toxicological Information
Oral (rat); LD50: >3 gm/kg. Intraperitoneal (rat); LD50: 278 mg/kg. Oral (mouse); LD50: >1300 mg/kg.
RTECS Data:
Intraperitoneal (mouse); LD50: 169 mg/kg.
Carcinogenic Effects:No data available
Mutagenic Effects:No data available
Tetratogenic Effects:No data available
SECTION 12: Ecological Information
Ecological Information:No information available
SECTION 13: Disposal Considerations
Disposal:Dispose of according to local, state and federal regulations.
SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA
SECTION 15: Regulatory Information
TSCA:Listed in the TSCA inventory.
SARA (Title 313):Not reportable under SARA Title 313
Second Ingredient:none

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TS5505000
CHEMICAL NAME :
2,18-Porphinedipropionic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride
CAS REGISTRY NUMBER :
17696-69-4
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C34-H38-N4-O6.2Cl-H
MOLECULAR WEIGHT :
671.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
278 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
169 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 117,145,1978

 Safety Information

Risk Phrases R33
RTECS TS5505000

 Synonyms

MFCD00013470
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, hydrochloride (1:2)
HEMATOPORPHYRIN DIHYDROCHLORIDE
EINECS 241-699-4
3,3'-[7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethylporphyrin-2,18-diyl]dipropanoic acid dihydrochloride
3,3'-[7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphyrindiyl]dipropanoic acid dihydrochloride
HAEMATOPORPHYRIN DIHYDROCHLORIDE
acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor
Hematoporphyrin (dihydrochloride)
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