DBeQ
Modify Date: 2024-01-02 11:19:07
DBeQ structure
|
Common Name | DBeQ | ||
|---|---|---|---|---|
| CAS Number | 177355-84-9 | Molecular Weight | 340.421 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 573.1±52.0 °C at 760 mmHg | |
| Molecular Formula | C22H20N4 | Melting Point | 149 °C | |
| MSDS | Chinese USA | Flash Point | 300.4±30.7 °C | |
Use of DBeQDBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM. |
| Name | N,N'-Dibenzyl-2,4-quinazolinediamine |
|---|---|
| Synonym | More Synonyms |
| Description | DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1.5 μM (p97)[1], 11.5 μM (Vps4)[2] |
| In Vitro | DBeQ is a ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively. DBeQ inhibits p97 competitively with respect to ATP, with a Ki of 3.2 ± 0.4 μM. DBeQ inhibits degradation of the p97-dependent substrate UbG76V-GFP, with IC50 value of 2.6 μM. DBeQ (10 μM) also significantly suppresses degradation of TCRα-GFP, induces CHOP but does not increase p21 level. Moreover, DBeQ inhibits the viability of MRC-5, Hek293, HeLa and RPMI8226 cells, with GI50s of 6.6 ± 2.9, 4 ± 0.6, 3.1 ± 0.5 and 1.2 ± 0.3, respectively[1]. DBeQ potently inhibits the AAA ATPase p97 by specifically binding to the ATPase site of its D2 domain (p97D2). DBeQ also inhibits Vps4, with an IC50 of 11.5 μM. Furthermore, DBeQ (30 μM) inhibits hyphal growth of the wild-type cell (strain YLZ0)[2]. |
| Cell Assay | Cells are seeded on a 384-well solid white plate (5,000 cells/well). Cells are transfected with luciferase siRNA or p97 siRNA (10 nM) for 48 h or treated with DBeQ for the indicated amount of time. Caspase-3/7 Glo, caspase-6 Glo, caspase-8 Glo, or caspase-9 Glo is added into each well and mixed by shaking at 500 rpm for 1 min. Luminescence signal is determined after incubation at room temperature for 1 h. Cellular viability is determined with CellTiter-Glo reagent. To determine the IC50 of cellular viability, cells are treated with MG132 or DBeQ at seven concentrations (threefold serial dilutions starting at 33 μM) for 48 h. IC50 values are calculated from fitting the percentage of luminescence signal normalized to DMSO treated cells)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 573.1±52.0 °C at 760 mmHg |
| Melting Point | 149 °C |
| Molecular Formula | C22H20N4 |
| Molecular Weight | 340.421 |
| Flash Point | 300.4±30.7 °C |
| Exact Mass | 340.168793 |
| PSA | 56.30000 |
| LogP | 4.34 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.735 |
| Storage condition | room temp |
| Water Solubility | DMSO: ≥20mg/mL |
| 2,4-dibenzylaminoquinazoline |
| N,N'-Dibenzyl-2,4-quinazolinediamine |
| 2,4-Quinazolinediamine, N,N-bis(phenylmethyl)- |
| DBeQ |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: DBeQ
- Price: Click To Check
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: DBeQ
- Price: ￥3896.0/50mg ￥2046.0/25mg ￥586.0/5mg ￥876.0/10mg
- Purity: 98.0%
- Delivery: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: DBeQ
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: DBeQ
- Price: $300.0/100mg $600.0/250mg $1200.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link:
Price: $79/10mM*1mLinDMSO
Reference only. check more DBeQ price