Prilocaine hydrochloride
Modify Date: 2024-01-02 11:36:45
Prilocaine hydrochloride structure
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Common Name | Prilocaine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1786-81-8 | Molecular Weight | 256.772 | |
| Density | N/A | Boiling Point | 85°C 4mm | |
| Molecular Formula | C13H21ClN2O | Melting Point | 168-170ºC | |
| MSDS | USA | Flash Point | 134.3ºC | |
Use of Prilocaine hydrochloridePrilocaine hydrochloride is a local anesthetic of the amino amide type.Target: OthersPrilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L?fgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia, for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue. Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500 mg.Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lidocaine and prilocaine in a cream was found to give effective topical analgesia in normal and diseased skin, making it useful for superficial surgery and various other clinical procedures. To be effective, an adequate amount must be applied under occlusion and at the right time before the intervention. |
| Name | prilocaine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Prilocaine hydrochloride is a local anesthetic of the amino amide type.Target: OthersPrilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L?fgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia, for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue. Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500 mg.Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lidocaine and prilocaine in a cream was found to give effective topical analgesia in normal and diseased skin, making it useful for superficial surgery and various other clinical procedures. To be effective, an adequate amount must be applied under occlusion and at the right time before the intervention. |
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| Related Catalog | |
| References |
[2]. Juhlin L, et al. EMLA: a new topical anesthetic. Adv Dermatol. 1990;5:75-91; discussion 92. |
| Boiling Point | 85°C 4mm |
|---|---|
| Melting Point | 168-170ºC |
| Molecular Formula | C13H21ClN2O |
| Molecular Weight | 256.772 |
| Flash Point | 134.3ºC |
| Exact Mass | 256.134247 |
| PSA | 41.13000 |
| LogP | 3.58750 |
| Vapour Pressure | 2.05E-05mmHg at 25°C |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| RTECS | UG5775000 |
| HS Code | 2924299090 |
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Methemoglobinemia induced by lidocaine-prilocaine cream.
Isr. Med. Assoc. J. 16(4) , 250-4, (2014) With growing awareness of the importance of pain control in all procedures, the use of lidocaine-prilocaine cream (EMLA) for all ages is increasing. Lidocaine-prilocaine cream has been implicated as a... |
| N-(α-Propylaminopropionyl)-o-toluidine hydrochloride |
| EINECS 217-244-0 |
| PrilocaineHydrochloroide |
| xylonest |
| Prilocaine hydrochloride |
| N-(2-Methylphenyl)-2-(propylamino)propanamidhydrochlorid |
| propitocaine hydrochloride |
| N-(2-Methylphenyl)-N-propylalaninamide hydrochloride |
| 3MY1&VMR B1 &&HCl |
| prilocainechloride |
| l-67hydrochloride |
| N-(2-Methylphenyl)-N-propylalaninamide hydrochloride (1:1) |
| N-(2-Methylphenyl)-2-(propylamino)propanamide hydrochloride |
| MFCD00079279 |
| Citanest Plain |
| PRILOCAINE HCL |
| Propanamide, N-(2-methylphenyl)-2-(propylamino)-, hydrochloride (1:1) |
| Propitocaine HCL |
| citanesthydrochloride |
| N-(2-methylphenyl)-N2-propylalaninamide hydrochloride |
| 2-(Propylamino)-N-(o-tolyl)propionamide Hydrochloride |
| Prilocaine HC |
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