RN-9893
Modify Date: 2024-04-11 21:33:27
RN-9893 structure
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Common Name | RN-9893 | ||
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| CAS Number | 1803003-68-0 | Molecular Weight | 500.491 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H23F3N4O5S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of RN-9893A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. |
| Name | RN-9893 |
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| Synonym | More Synonyms |
| Description | A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. |
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| References | References 1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5. View Related Products by Target TRP Channel |
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C21H23F3N4O5S |
| Molecular Weight | 500.491 |
| Exact Mass | 500.134125 |
| LogP | 4.26 |
| Index of Refraction | 1.584 |
| RIDADR | NONH for all modes of transport |
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TRPV4 agonists and antagonists. Vincent F and Duncton MA
Curr. Top. Med. Chem 11(17) , 2216-26, (2011)
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Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Wei ZL et al
BioTechnol.: Indian J. 25(18) , 4011-5, (2015)
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| N-{4-[(4-Isopropyl-1-piperazinyl)sulfonyl]phenyl}-2-nitro-4-(trifluoromethyl)benzamide |
| Benzamide, N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)- |
| MFCD29917838 |
| RN-9893 |
| N-(4-(4-Isopropylpiperazin-1-ylsulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide |