Colesevelam Hydrochloride

Modify Date: 2024-01-05 14:12:20

Colesevelam Hydrochloride Structure
Colesevelam Hydrochloride structure
 Common Name Colesevelam Hydrochloride
CAS Number 182815-44-7 Molecular Weight 618.24900
Density N/A Boiling Point N/A
Molecular Formula (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl Melting Point >145℃ (dec.)
MSDS N/A Flash Point N/A

 Use of Colesevelam Hydrochloride


Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.

 Names

Name colesevelam hydrochloride
Synonym More Synonyms

 Colesevelam Hydrochloride Biological Activity

Description Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.
Related Catalog
References

[1]. Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G371-G380.

[2]. Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10(6):1496.

 Chemical & Physical Properties

Melting Point >145℃ (dec.)
Molecular Formula (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl
Molecular Weight 618.24900
Exact Mass 616.43800
PSA 62.61000
LogP 5.97450
Storage condition -20°C

 Synonyms

colesevelam
2-(chloromethyl)oxirane,prop-2-en-1-amine,N-prop-2-enyldecan-1-amine,trimethyl-[6-(prop-2-enylamino)hexyl]azanium,chloride,hydrochloride
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Chemsrc provides Colesevelam Hydrochloride(CAS#:182815-44-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Colesevelam Hydrochloride are included as well.>> amp version: Colesevelam Hydrochloride

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