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182815-44-7

182815-44-7 structure
182815-44-7 structure
  • Name: Colesevelam Hydrochloride
  • Chemical Name: colesevelam hydrochloride
  • CAS Number: 182815-44-7
  • Molecular Formula: (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl
  • Molecular Weight: 618.24900
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2018-08-24 18:39:49
  • Modify Date: 2024-01-05 14:12:20
  • Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.

Name colesevelam hydrochloride
Synonyms colesevelam
2-(chloromethyl)oxirane,prop-2-en-1-amine,N-prop-2-enyldecan-1-amine,trimethyl-[6-(prop-2-enylamino)hexyl]azanium,chloride,hydrochloride
Description Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease.
Related Catalog
References

[1]. Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G371-G380.

[2]. Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10(6):1496.

Melting Point >145℃ (dec.)
Molecular Formula (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl
Molecular Weight 618.24900
Exact Mass 616.43800
PSA 62.61000
LogP 5.97450
Storage condition -20°C