AC-4-130

Modify Date: 2024-01-05 20:28:05

AC-4-130 Structure
AC-4-130 structure
 Common Name AC-4-130
CAS Number 1834571-82-2 Molecular Weight 751.206
Density N/A Boiling Point N/A
Molecular Formula C37H36ClF5N2O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AC-4-130


AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.

 Names

Name AC-4-130

 AC-4-130 Biological Activity

Description AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.
References References 1. Wingelhofer B, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0005-9. View Related Products by Target STAT

 Chemical & Physical Properties

Molecular Formula C37H36ClF5N2O5S
Molecular Weight 751.206
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Chemsrc provides AC-4-130(CAS#:1834571-82-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AC-4-130 are included as well.>> amp version: AC-4-130

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