2711006-67-4
2711006-67-4 structure
- Name: ZXH-4-130 TFA
- Chemical Name: ZXH-4-130 TFA
- CAS Number: 2711006-67-4
- Molecular Formula: C48H59F3N6O11S
- Molecular Weight: 985.08
- Catalog: Signaling Pathways PROTAC PROTAC
- Create Date: 2022-03-28 07:16:01
- Modify Date: 2024-01-12 09:53:15
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ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC)[1].
| Name | ZXH-4-130 TFA |
|---|
| Description | ZXH-4-130 TFA is a highly potent and selective degrader of CRBN. ZXH-4-130 is a CRBN-VHL compound (hetero-PROTAC)[1]. |
|---|---|
| Related Catalog | |
| Target |
VHL |
| In Vitro | ZXH-4-130 (100 nM; 2 h pre-treatments; followed by 96-hour treatment with 1 μM of Pomalidomide) TFA prevents Pomalidomide (1 μM) cytotoxicity to a significant extent, ZXH-4-130 TFA has statistically significant amounts of prevention[1]. MM1.S cells are pre-treated for 2 h with 50 nM of ZXH-4-130 TFA, before exposing them to CC-885, a compound that induces G1 to S phase transition protein 1 (GSPT1) degradation via CRBN E3 ligase recruitment. Pretreatment with 50 nM of ZXH-4-130 TFA rescues GSPT1 degradation[1]. ZXH-4-130 (100 nM 2 h pre-treatment; followed by 6 h treatment with THAL-SNS-032)TFA induces nearly complete CRBN degradation, but THAL-SNS-032's activity against CDK9 is only partially prevented[1]. |
| References |
| Molecular Formula | C48H59F3N6O11S |
|---|---|
| Molecular Weight | 985.08 |