1834571-82-2

1834571-82-2 structure

Name: AC-4-130
Chemical Name: AC-4-130
CAS Number: 1834571-82-2
Molecular Formula: C₃₇H₃₆ClF₅N₂O₅S
Molecular Weight: 751.206
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2020-01-12 17:10:23
Modify Date: 2024-01-05 20:28:05
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.

Name	AC-4-130

Description	AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.
References	References 1. Wingelhofer B, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0005-9. View Related Products by Target STAT

Molecular Formula	C₃₇H₃₆ClF₅N₂O₅S
Molecular Weight	751.206