ACT 709478
Modify Date: 2024-01-19 13:27:57
ACT 709478 structure
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Common Name | ACT 709478 | ||
|---|---|---|---|---|
| CAS Number | 1838651-58-3 | Molecular Weight | 425.41 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18F3N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ACT 709478ACT-709478 is a potent, selective, oral active, and brain penetrating T-type calcium channel blocker, with IC50s of 6.4, 18, 7.5 and 2410 nM for Cav3.1, Cav3.2, Cav3.3, Cav1.2, respectively. ACT-709478 is effective on rat and mice, dog, and cynomolgus T-type calcium channel, with no significant species differences. ACT-709478 is used in the research of generalized epilepsies[1]. |
| Name | ACT-709478 |
|---|
| Description | ACT-709478 is a potent, selective, oral active, and brain penetrating T-type calcium channel blocker, with IC50s of 6.4, 18, 7.5 and 2410 nM for Cav3.1, Cav3.2, Cav3.3, Cav1.2, respectively. ACT-709478 is effective on rat and mice, dog, and cynomolgus T-type calcium channel, with no significant species differences. ACT-709478 is used in the research of generalized epilepsies[1]. |
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| Related Catalog | |
| Target |
Cav3.1:6.4 nM (IC50) Cav3.2:18 nM (IC50) Cav3.3:7.5 nM (IC50) Cav1.2:2410 nM (IC50) |
| In Vitro | ACT-709478 (Compound 66b) blocks currents through hKv11.1-hERG channels with an IC50 of 5.5 μM[1]. ACT-709478 shows weak inhibition on P450, with IC50s of 52, 14, 22, 25, 15, and 51 μM for P4502A6, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4, respectively[1]. |
| References |
| Molecular Formula | C22H18F3N5O |
|---|---|
| Molecular Weight | 425.41 |
| Storage condition | 2-8℃ |