1258417-54-7

1258417-54-7 structure

Name: ACT-389949
Chemical Name: ACT-389949
CAS Number: 1258417-54-7
Molecular Formula: C₂₀H₁₈F₂N₆O₃
Molecular Weight: 428.39
Catalog: Signaling Pathways Others Others
Create Date: 2019-12-08 14:39:19
Modify Date: 2024-01-04 21:33:00
ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].

Name	ACT-389949

Description	ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. ACT-389949 has potential for the treatment of inflammatory disorders[1][2].
Related Catalog	Signaling Pathways >> Others >> Others
Target	(FPR2)/(ALX)[1]
In Vivo	ACT-389949 has well tolerated. Maximum concentrations are reached around 2 hours after dosing, with a mean terminal half-life of 29.3 hours[1]. Administration of ACT-389949 results in a dose-dependent, long-lasting internalization of FPR2/ALX into leukocytes[1].
References	[1]. Stalder AK,et al. Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949. Br J Clin Pharmacol. 2017 Mar;83(3):476-486. [2]. Lind S, et al. Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949. Biochem Pharmacol. 2019 Aug;166:163-173.

Molecular Formula	C₂₀H₁₈F₂N₆O₃
Molecular Weight	428.39