FF-10502
Modify Date: 2024-01-11 12:06:07
FF-10502 structure
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Common Name | FF-10502 | ||
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| CAS Number | 184302-49-6 | Molecular Weight | 261.273 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 516.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C9H12FN3O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 266.2±32.9 °C | |
| Name | 4-Amino-1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone |
|---|---|
| Synonym | More Synonyms |
| Description | |
|---|---|
| In Vitro | FF-10502 (FF-10502-01) is a pyrimidine nucleoside antimetabolite that shows growth inhibition of pancreatic cancer cell lines with IC50 of 60-330 nM; FF-10502 is far more potent than gemcitabine in inhibiting DNA polymerase ��, significantly induces concentration-dependent cell death in accordance with enhanced DNA damage in combination with DNA damage inducers (H2O2, cisplatin, and temozolomide); also demonstrates complete tumor growth suppression in in vivo patient-derived xenograft models with gemcitabine-resistant pancreatic cancer cells. |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 516.5±60.0 °C at 760 mmHg |
| Molecular Formula | C9H12FN3O3S |
| Molecular Weight | 261.273 |
| Flash Point | 266.2±32.9 °C |
| Exact Mass | 261.058350 |
| LogP | -1.73 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.754 |
| 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)- |
| 4-Amino-1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone |